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KPV (α-MSH Tripeptide) 10mg – Anti-Inflammatory Fragment

$65.00

In stock

SKU: pw-kpv-10 Categories: , ,

Description

KPV 10mg is a synthetic C-terminal tripeptide fragment (Lysine-Proline-Valine) derived from the hormone Alpha-Melanocyte Stimulating Hormone ($\alpha$-MSH). Unlike the full-length hormone or analogs like Melanotan II, KPV does not bind to the MC1R receptor responsible for pigmentation, making it a non-pigmentary reagent.

This peptide is the subject of rigorous investigation regarding its potent anti-inflammatory, antimicrobial, and cytoprotective properties, particularly within mucosal tissues and the integumentary system.

Mechanism: NF-κB Inhibition & Host Defense

KPV retains the specific anti-inflammatory pharmacophore of $\alpha$-MSH but exhibits a distinct mechanism of action focused on immune modulation.

  • NF-κB Inhibition: Research demonstrates that KPV enters cells (often via the PepT1 transporter in intestinal models) and interacts directly with the nucleus to inhibit the Nuclear Factor-kappa B (NF-κB) pathway. This downregulation suppresses the transcription of pro-inflammatory cytokines such as TNF-$\alpha$, IL-6, and IL-1$\beta$.

  • Antimicrobial Activity: In vitro studies have highlighted KPV’s direct antimicrobial effects against specific pathogens, including Staphylococcus aureus and Candida albicans, suggesting a role in innate host defense.

  • Mast Cell Modulation: The peptide is also investigated for its ability to stabilize mast cells, potentially reducing histamine release in allergic response models.

This research peptide undergoes rigorous quality control and stability testing to ensure maximum integrity for scientific applications. Each batch is manufactured under strict laboratory conditions and verified through independent laboratory analysis.

⚠️ FOR RESEARCH PURPOSES ONLY

This product is strictly for in-vitro laboratory research, analysis, and development. It is not intended for human consumption, injection, or therapeutic use. KPV is not a drug.

Storage & Handling

Peptides require careful storage to maintain their integrity and research effectiveness. Lyophilized peptides should be stored in a cold, dry, dark environment to prevent degradation. For short-term use within 4 weeks, storage at 4°C is sufficient, while long-term storage requires temperatures below -20°C or -80°C for extended periods up to 2 years. Always protect peptides from light exposure and avoid repeated freeze-thaw cycles, which can compromise structural integrity and research results.

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Legal Disclaimer & Safety Information

This product is sold as a pure research compound exclusively for laboratory research purposes and is not intended for use as a dietary supplement, medication, or for human/animal consumption. These research chemicals have not been evaluated by the U.S. Food and Drug Administration (FDA) and are not pharmaceuticals, medications, or dietary supplements. They have not received FDA approval for the treatment, prevention, diagnosis, mitigation, or cure of any disease, medical condition, or ailment. Keep this product out of the reach of children and unauthorized personnel, as this material may result in adverse effects if improperly handled or consumed. This product is for use and handling only by qualified professionals with the knowledge, training, and equipment to safely handle research chemicals. Under no circumstances should these products be utilized as drugs, agricultural or pesticide products, food additives, or household chemicals, and any form of introduction into the human or animal body is prohibited by law. By making a purchase from Peptideware, you acknowledge that you are acquiring research chemicals exclusively intended for in-vitro laboratory research use by qualified and licensed professionals only. All articles, information, and product descriptions provided on this website are strictly for educational and informational purposes. We attest exclusively to the quality, purity, and description of the materials we provide. Misrepresentation of these products for unauthorized purposes is strictly prohibited by law. You agree to indemnify and hold us harmless for any adverse effects, claims, expenses, losses, and liabilities that may arise from improper handling, misuse, or consumption of this product. Please refer to our terms and conditions prior to purchase.