Selank N-Acetyl 5mg anxiolytic nootropic peptide for cognitive research
Selank N-Acetyl 5mg anxiolytic peptide vial label with batch information
Selank N-Acetyl 5mg Certificate of Analysis COA document
Selank N-Acetyl 5mg anxiolytic nootropic peptide for cognitive research
Selank N-Acetyl 5mg anxiolytic peptide vial label with batch information
Selank N-Acetyl 5mg Certificate of Analysis COA document

Selank (N-Acetyl Selank) 5mg – Anxiolytic Peptide

$40.00

Selank is a synthetic heptapeptide derivative of the naturally occurring immunomodulatory peptide Tuftsin (Thr-Lys-Pro-Arg). This 5mg lyophilized vial contains the N-Acetyl version, modified to improve metabolic stability and bioavailability.

In research settings, Selank is primarily investigated for its anxiolytic (anti-anxiety) and nootropic (cognitive enhancing) properties. It is unique among anxiolytic agents for its ability to reduce anxiety without inducing the sedation, muscle relaxation, or cognitive dampening often associated with traditional benzodiazepines.

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Description

What Is Selank?

Selank is a synthetic heptapeptide derived from the naturally occurring immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg). The N-Acetyl modification improves metabolic stability. Approved as an anxiolytic in Russia, Selank is studied for its effects on BDNF expression, enkephalin modulation, and immune regulation. HPLC-verified at 99%+ purity with publicly available COA.

Why Researchers Choose Selank

  • Tuftsin-Derived Heptapeptide — Derived from the naturally occurring immunopeptide tuftsin (fragment 289-292 of IgG heavy chain), providing a well-characterized research foundation.
  • N-Acetyl Modification for Enhanced Stability — The N-terminal acetylation significantly increases resistance to peptidase degradation, extending the useful research window.
  • Anxiolytic Without Sedation in Preclinical Models — Published studies suggest anxiolytic-like activity in animal models without the sedative effects commonly associated with GABAergic compounds.
  • Dual Anxiolytic + Immunomodulatory Pathways — Preclinical research indicates Selank simultaneously modulates GABA receptor activity and immune system signaling, a combination rarely found in a single peptide.
  • Verified Purity: ≥99% (HPLC) — Every batch is independently verified to ensure maximum integrity for laboratory applications.

Frequently Asked Questions

What is Selank?

Selank is a synthetic heptapeptide derived from the endogenous immunomodulatory peptide tuftsin, with an N-Acetyl modification added to improve enzymatic stability. It was originally developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. Published studies suggest it modulates GABAergic, serotonergic, and dopaminergic neurotransmission, making it a subject of active preclinical research in stress-response and immune regulation models.

How do I reconstitute Selank for laboratory use?

Add 1 mL of bacteriostatic water to the 5 mg vial to achieve a working concentration of 5 mg/mL. Direct the stream of water down the inside wall of the vial rather than directly onto the lyophilized cake. Swirl gently — do not shake. Allow up to 5 minutes for complete dissolution before use in research protocols.

What purity standard does this product meet?

Every batch is verified at ≥99% purity via high-performance liquid chromatography (HPLC) through independent third-party laboratory analysis.

How should Selank be stored?

Store the lyophilized powder at -20°C or below for long-term stability (up to 24 months). Once reconstituted, store at 2-8°C and use within 4 weeks. Protect from light and avoid repeated freeze-thaw cycles, which can compromise peptide integrity.

What is the difference between Selank and Semax?

While both are synthetic heptapeptides studied in neuroscience research, they target different pathways. Selank is primarily investigated for its anxiolytic and immunomodulatory properties through GABA receptor modulation and enkephalin stabilization. Semax, an ACTH(4-10) analog, is primarily studied for its nootropic and neurotrophic properties through BDNF and NGF upregulation. Researchers often study these compounds in complementary protocols.

What does published research say about Selank?

Preclinical research indicates Selank modulates the expression of genes related to GABAergic neurotransmission, inhibits enkephalin-degrading enzymes to extend endogenous opioid peptide activity, and influences the balance of Th1/Th2 immune responses. Studies have examined its effects on anxiety-like behaviors in animal models and its influence on monoamine metabolism in the central nervous system.

Can Selank be used in combination research protocols?

Published studies have examined Selank alongside other neuroactive peptides such as Semax. Researchers investigating complementary anxiolytic and cognitive pathways may design protocols that incorporate multiple compounds. Always refer to peer-reviewed literature when designing multi-compound research protocols.

Further Reading

New to peptide research? Visit our Peptide Reconstitution 101 guide for step-by-step instructions on proper handling, storage, and reconstitution techniques.

Mechanism: Enkephalin Regulation & Neuroplasticity

The pharmacological profile of Selank is characterized by its modulation of the central nervous system’s endogenous regulatory systems:

  • Enkephalin Hydrolysis Inhibition: Selank inhibits the enzymatic breakdown of endogenous enkephalins (natural opioid peptides). By extending the half-life of these molecules, it promotes a sustained sense of well-being and stress resilience.

  • Monoamine Modulation: Research indicates Selank influences the metabolism of key neurotransmitters—Serotonin, Dopamine, and Norepinephrine—in the brain, potentially improving mood stability and cognitive focus.

  • BDNF Upregulation: Studies suggest that Selank administration leads to increased expression of Brain-Derived Neurotrophic Factor (BDNF) in the hippocampus, supporting neuroplasticity, memory formation, and learning capacity.

This research peptide undergoes rigorous quality control and stability testing to ensure maximum integrity for scientific applications. Each batch is manufactured under strict laboratory conditions and verified through independent laboratory analysis.

⚠️ FOR RESEARCH PURPOSES ONLY

This product is strictly for in-vitro laboratory research, analysis, and development. It is not intended for human consumption, injection, or therapeutic use. Selank is not a drug or medical treatment for anxiety.

Technical Specifications

  • Sequence: N-Acetyl-Thr-Lys-Pro-Arg-Pro-Gly-Pro

  • Parent Molecule: Tuftsin (Fragment 289-292 of IgG heavy chain)

  • Formula: {33}H_{57}N_{11}O_{9}$

  • Molar Mass: ~751.9 g/mol

  • Purity: ≥99% (HPLC Verified)

  • Form: Lyophilized White Powder

  • Stability: N-Acetyl modification enhances resistance to peptidase degradation.

Storage & Handling

Peptides require careful storage to maintain their integrity and research effectiveness. Lyophilized peptides should be stored in a cold, dry, dark environment to prevent degradation. For short-term use within 4 weeks, storage at 4°C is sufficient, while long-term storage requires temperatures below -20°C or -80°C for extended periods up to 2 years. Always protect peptides from light exposure and avoid repeated freeze-thaw cycles, which can compromise structural integrity and research results.

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Legal Disclaimer & Safety Information

This product is sold as a pure research compound exclusively for laboratory research purposes and is not intended for use as a dietary supplement, medication, or for human/animal consumption. These research chemicals have not been evaluated by the U.S. Food and Drug Administration (FDA) and are not pharmaceuticals, medications, or dietary supplements. They have not received FDA approval for the treatment, prevention, diagnosis, mitigation, or cure of any disease, medical condition, or ailment. Keep this product out of the reach of children and unauthorized personnel, as this material may result in adverse effects if improperly handled or consumed. This product is for use and handling only by qualified professionals with the knowledge, training, and equipment to safely handle research chemicals. Under no circumstances should these products be utilized as drugs, agricultural or pesticide products, food additives, or household chemicals, and any form of introduction into the human or animal body is prohibited by law. By making a purchase from Peptideware, you acknowledge that you are acquiring research chemicals exclusively intended for in-vitro laboratory research use by qualified and licensed professionals only. All articles, information, and product descriptions provided on this website are strictly for educational and informational purposes. We attest exclusively to the quality, purity, and description of the materials we provide. Misrepresentation of these products for unauthorized purposes is strictly prohibited by law. You agree to indemnify and hold us harmless for any adverse effects, claims, expenses, losses, and liabilities that may arise from improper handling, misuse, or consumption of this product. Please refer to our terms and conditions prior to purchase.