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Semaglutide 10mg GLP-1 agonist lyophilized peptide for metabolic research
Semaglutide 10mg GLP-1 agonist research vial label with batch information
Semaglutide 10mg Certificate of Analysis COA document
Semaglutide 10mg GLP-1 agonist lyophilized peptide for metabolic research
Semaglutide 10mg GLP-1 agonist research vial label with batch information
Semaglutide 10mg Certificate of Analysis COA document

Semaglutide (GLP-1 Agonist) 10mg – Lyophilized Peptide

Original price was: $85.00.Current price is: $75.00.

10mg establishes the benchmark for Glucagon-Like Peptide-1 (GLP-1) receptor agonist research. As a long-acting analogue with 94% structural homology to native human GLP-1, this peptide is the essential “Reference Standard” for laboratories investigating metabolic signaling, insulin kinetics, and neuroendocrine regulation.

Our 10mg lyophilized preparation is rigorously synthesized to achieve ≥99% purity (HPLC), providing the consistency required for high-stakes comparative analysis against emerging multi-agonist compounds.

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Description

What Is Semaglutide?

Semaglutide is a synthetic GLP-1 receptor agonist (MW: 4,113 Da, CAS: 910463-68-2) with a C-18 fatty acid chain enabling a 7-day half-life. The STEP 1 trial reported 14.9% mean weight reduction over 68 weeks (n=1,961). The SELECT trial showed 20% reduction in major cardiovascular events. One of the most extensively studied peptides in metabolic research. HPLC-verified at 99%+ purity with publicly available COA.

Why Researchers Choose Semaglutide

  • 94% structural homology to native human GLP-1 — the benchmark reference standard for GLP-1 research
  • Long-acting profile with albumin binding for extended pharmacokinetic research models
  • ≥99% purity verified via independent third-party HPLC and mass spectrometry
  • Extensively published GLP-1 receptor agonist with thousands of indexed research papers
  • 10mg lyophilized format optimized for precision metabolic and neuroendocrine research

Frequently Asked Questions

What is Semaglutide and what research applications does it support?

Semaglutide is a synthetic GLP-1 analog with 94% structural homology to native human GLP-1. It is investigated in research protocols focused on metabolic signaling, insulin kinetics, and neuroendocrine regulation. This compound is sold strictly for laboratory research purposes only.

How do I reconstitute Semaglutide for laboratory use?

Add 2mL of bacteriostatic water to yield a concentration of 5mg/mL. Direct the stream against the glass wall of the vial and gently roll to dissolve — do not shake. For detailed reconstitution research protocols, see our Reconstitution 101 guide.

What purity verification does Peptideware provide for Semaglutide?

Every batch of Semaglutide undergoes independent third-party HPLC testing confirming ≥99% purity, along with mass spectrometry confirmation of molecular identity. A Certificate of Analysis (COA) is available for each lot.

How should I store Semaglutide before and after reconstitution?

In lyophilized form, store at -20°C for long-term storage or 2-8°C for short-term storage. Once reconstituted for research, store at 2-8°C and use within 28 days for optimal stability.

How does Semaglutide differ from Tirzepatide in research?

Semaglutide is a single GLP-1 receptor agonist, while Tirzepatide is a dual GIP/GLP-1 receptor agonist (often called a “Twincretin”). They offer different receptor activation profiles suited to different metabolic research models.

What published research exists on Semaglutide?

Thousands of indexed studies on PubMed examine Semaglutide in preclinical research contexts covering metabolic signaling, body composition analysis, and glycemic research models. All references are provided in a preclinical research context.

Can Semaglutide be used in comparison research protocols?

Yes. Semaglutide is frequently used as the reference standard alongside Tirzepatide (dual agonist) and Retatrutide (triple agonist) in comparative incretin research protocols. Peptideware carries all three compounds for comprehensive research.

Further Reading

Mechanism: DPP-4 Resistance & Albumin Binding

Semaglutide owes its distinct pharmacological profile to specific structural modifications that overcome the rapid degradation seen in native GLP-1.

  • Amino Acid Substitution: The substitution of Alanine with α-aminoisobutyric acid (Aib) at position 8 renders the peptide resistant to degradation by the enzyme dipeptidyl peptidase-4 (DPP-4).

  • Albumin Affinity: The critical innovation is the acylation of the peptide backbone with a C-18 fatty diacid side chain. This spacer allows Semaglutide to bind non-covalently to serum albumin with high affinity.

  • Extended Half-Life: This albumin binding serves a dual purpose: it shields the peptide from renal clearance and enzymatic breakdown, extending the plasma half-life to approximately 7 days (165 hours) in research models.

This research peptide undergoes rigorous quality control and stability testing to ensure maximum integrity for scientific applications. Each batch is manufactured under strict laboratory conditions and verified through independent laboratory analysis.

⚠️ FOR RESEARCH PURPOSES ONLY

This product is strictly for in-vitro laboratory research, analysis, and development. It is not intended for human consumption, injection, or therapeutic use. Semaglutide is not a drug, dietary supplement, or food. It is a research chemical. All statements regarding the physiological mechanisms of Semaglutide are based on preclinical animal and cell-culture studies and are provided for educational and informational purposes only.

Primary Research Targets

Semaglutide is the primary subject of study for the following physiological pathways:

  1. Glucose-Dependent Insulin Secretion: Investigating the stimulation of pancreatic beta-cells to release insulin only when glucose levels are elevated.

  2. Glucagon Suppression: Studying the inhibition of inappropriate glucagon secretion from alpha-cells.

  3. Gastric Motility: Analyzing the delay in gastric emptying rates, a mechanism linked to satiety signaling via the Vagus nerve.

The “Control Standard” for Comparative Studies: In the current landscape of metabolic research, Semaglutide serves as the Control Standard. It is the baseline against which the efficacy of novel “Twin” (Tirzepatide) and “Triple” (Retatrutide) agonists are measured in preclinical trials.

Technical Specifications

  • CAS Number: 910463-68-2

  • Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉

  • Molar Mass: 4113.58 g/mol

  • Sequence: Modified GLP-1 (7-37) backbone with C-18 fatty acid chain

  • Purity: ≥99% (HPLC Verified)

  • Form: Lyophilized White Powder

  • Semaglutide Certificate of Analysis from independent third-party laboratory
  • Semaglutide HPLC chromatogram showing 99%+ purity verification
  • Semaglutide mass spectrometry analysis confirming molecular identity

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Legal Disclaimer & Safety Information

This product is sold as a pure research compound exclusively for laboratory research purposes and is not intended for use as a dietary supplement, medication, or for human/animal consumption. These research chemicals have not been evaluated by the U.S. Food and Drug Administration (FDA) and are not pharmaceuticals, medications, or dietary supplements. They have not received FDA approval for the treatment, prevention, diagnosis, mitigation, or cure of any disease, medical condition, or ailment. Keep this product out of the reach of children and unauthorized personnel, as this material may result in adverse effects if improperly handled or consumed. This product is for use and handling only by qualified professionals with the knowledge, training, and equipment to safely handle research chemicals. Under no circumstances should these products be utilized as drugs, agricultural or pesticide products, food additives, or household chemicals, and any form of introduction into the human or animal body is prohibited by law. By making a purchase from Peptideware, you acknowledge that you are acquiring research chemicals exclusively intended for in-vitro laboratory research use by qualified and licensed professionals only. All articles, information, and product descriptions provided on this website are strictly for educational and informational purposes. We attest exclusively to the quality, purity, and description of the materials we provide. Misrepresentation of these products for unauthorized purposes is strictly prohibited by law. You agree to indemnify and hold us harmless for any adverse effects, claims, expenses, losses, and liabilities that may arise from improper handling, misuse, or consumption of this product. Please refer to our terms and conditions prior to purchase.