Semax ACTH fragment 4-10 10mg neurogenic peptide for cognitive research
Semax ACTH fragment 10mg neurogenic peptide vial label with batch information
Semax ACTH fragment 10mg Certificate of Analysis COA document
Semax ACTH fragment 4-10 10mg neurogenic peptide for cognitive research
Semax ACTH fragment 10mg neurogenic peptide vial label with batch information
Semax ACTH fragment 10mg Certificate of Analysis COA document

Semax (ACTH Fragment 4-10) 10mg – Neurogenic Peptide

$40.00

Semax is a synthetic heptapeptide analogue of the Adrenocorticotropic Hormone (ACTH) fragment 4-10. This 10mg lyophilized peptide is engineered to retain the neurogenic and cognitive-enhancing properties of its parent molecule while being completely devoid of hormonal activity.

Unlike psychostimulants that deplete neuronal reserves, Semax is investigated for its functional role as a “regulatory peptide,” modulating the expression of neurotrophins and optimizing the brain’s default mode network (DMN).

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Description

What Is Semax?

Semax is a synthetic heptapeptide analog of the ACTH fragment 4-10. It retains neurogenic and cognitive-enhancing properties without adrenal stimulation. Research focuses on BDNF upregulation, neuroprotection, and cognitive performance. Approved as a nootropic in Russia. HPLC-verified at 99%+ purity with publicly available COA.

Why Researchers Choose Semax

  • ACTH Fragment 4-10 Analog — Derived from the biologically active core of adrenocorticotropic hormone, retaining neurotrophic properties while eliminating hormonal activity.
  • Neurotrophic Factor Modulation (BDNF/NGF) — Published studies suggest Semax rapidly upregulates Brain-Derived Neurotrophic Factor and Nerve Growth Factor expression in key brain regions.
  • No Hormonal Activity Despite ACTH Origin — Preclinical research indicates Semax does not stimulate the adrenal cortex or alter cortisol levels, isolating the nootropic properties from the parent hormone.
  • Verified Purity: ≥99% (HPLC) — Every batch undergoes independent third-party laboratory verification to ensure maximum integrity for research applications.
  • 10 mg Format for Cognitive Research — Higher-quantity vials designed for extended research protocols investigating neuroplasticity and neurotransmitter dynamics.

Frequently Asked Questions

What is Semax?

Semax is a synthetic heptapeptide analog of the ACTH(4-10) fragment, originally developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It is one of the most studied nootropic peptides in preclinical literature, with research focusing on its ability to modulate neurotrophic factor expression, neurotransmitter turnover, and neuroprotective pathways without producing hormonal or endocrine effects.

How do I reconstitute Semax for laboratory use?

Add 2 mL of bacteriostatic water to the 10 mg vial to achieve a working concentration of 5 mg/mL. Direct the stream of water down the inside wall of the vial rather than directly onto the lyophilized cake. Swirl gently — do not shake. Allow up to 5 minutes for complete dissolution before use in research protocols.

What purity standard does this product meet?

Every batch is verified at ≥99% purity via high-performance liquid chromatography (HPLC) through independent third-party laboratory analysis.

How should Semax be stored?

Store the lyophilized powder at -20°C or below for long-term stability (up to 24 months). Once reconstituted, store at 2-8°C and use within 4 weeks. Protect from light and avoid repeated freeze-thaw cycles to maintain structural integrity.

What is the difference between Semax and Selank?

Semax and Selank are complementary but mechanistically distinct peptides. Semax is primarily studied for its nootropic and neurotrophic properties — it upregulates BDNF and NGF, modulates dopamine and serotonin turnover, and is investigated in neuroplasticity research. Selank, a tuftsin-derived peptide, is primarily studied for its anxiolytic and immunomodulatory properties through GABA modulation and enkephalin stabilization. Researchers frequently study both in complementary protocols.

What does published research say about Semax?

Preclinical research indicates Semax rapidly increases BDNF and NGF expression in the hippocampus and forebrain, enhances dopamine and serotonin turnover in the CNS, and modulates functional connectivity between brain networks in imaging studies. Published studies suggest neuroprotective effects in ischemia models, and research continues into its influence on synaptic plasticity and long-term memory formation.

Can Semax be used in combination research protocols?

Published studies have examined Semax alongside other neuropeptides, including Selank. Researchers investigating complementary nootropic and anxiolytic pathways often design protocols incorporating multiple compounds targeting distinct neurotransmitter systems. Always consult peer-reviewed literature when designing multi-compound research protocols.

Further Reading

New to peptide research? Visit our Peptide Reconstitution 101 guide for step-by-step instructions on proper handling, storage, and reconstitution techniques.

Mechanism: BDNF Upregulation & Neuroprotection

Semax is unique in its ability to modulate the central nervous system through gene expression and neurotrophic support:

  • BDNF & NGF Synthesis: Research demonstrates that Semax rapidly upregulates the expression of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) in the hippocampus and forebrain. These proteins are critical for neuronal survival, synaptic plasticity, and long-term memory formation.

  • Default Mode Network (DMN): fMRI studies suggest Semax modulates the connection between the DMN and task-positive networks, potentially enhancing resting-state functional connectivity and attention switching.

  • Neurotransmitter Turnover: The peptide is observed to increase the turnover of dopamine and serotonin, improving neurotransmission efficiency without the neurotoxicity associated with amphetamine-class compounds.

This research peptide undergoes rigorous quality control and stability testing to ensure maximum integrity for scientific applications. Each batch is manufactured under strict laboratory conditions and verified through independent laboratory analysis.

⚠️ FOR RESEARCH PURPOSES ONLY

This product is strictly for in-vitro laboratory research, analysis, and development. It is not intended for human consumption, injection, or therapeutic use. Semax is not a drug.

Technical Specifications

  • Sequence: Met-Glu-His-Phe-Pro-Gly-Pro

  • Identity: Synthetic ACTH (4-10) Analogue

  • Formula: {37}H_{51}N_{9}O_{10}S$

  • Molar Mass: ~813.9 g/mol

  • CAS Number: 80714-61-0

  • Purity: ≥99% (HPLC Verified)

  • Form: Lyophilized White Powder

Storage & Handling

Peptides require careful storage to maintain their integrity and research effectiveness. Lyophilized peptides should be stored in a cold, dry, dark environment to prevent degradation. For short-term use within 4 weeks, storage at 4°C is sufficient, while long-term storage requires temperatures below -20°C or -80°C for extended periods up to 2 years. Always protect peptides from light exposure and avoid repeated freeze-thaw cycles, which can compromise structural integrity and research results.

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Legal Disclaimer & Safety Information

This product is sold as a pure research compound exclusively for laboratory research purposes and is not intended for use as a dietary supplement, medication, or for human/animal consumption. These research chemicals have not been evaluated by the U.S. Food and Drug Administration (FDA) and are not pharmaceuticals, medications, or dietary supplements. They have not received FDA approval for the treatment, prevention, diagnosis, mitigation, or cure of any disease, medical condition, or ailment. Keep this product out of the reach of children and unauthorized personnel, as this material may result in adverse effects if improperly handled or consumed. This product is for use and handling only by qualified professionals with the knowledge, training, and equipment to safely handle research chemicals. Under no circumstances should these products be utilized as drugs, agricultural or pesticide products, food additives, or household chemicals, and any form of introduction into the human or animal body is prohibited by law. By making a purchase from Peptideware, you acknowledge that you are acquiring research chemicals exclusively intended for in-vitro laboratory research use by qualified and licensed professionals only. All articles, information, and product descriptions provided on this website are strictly for educational and informational purposes. We attest exclusively to the quality, purity, and description of the materials we provide. Misrepresentation of these products for unauthorized purposes is strictly prohibited by law. You agree to indemnify and hold us harmless for any adverse effects, claims, expenses, losses, and liabilities that may arise from improper handling, misuse, or consumption of this product. Please refer to our terms and conditions prior to purchase.