CJC-1295 No DAC Mod GRF 1-29 10mg lyophilized peptide for GH research
CJC-1295 No DAC 10mg research vial label with batch information
CJC-1295 No DAC 10mg Certificate of Analysis COA document
CJC-1295 No DAC Mod GRF 1-29 10mg lyophilized peptide for GH research
CJC-1295 No DAC 10mg research vial label with batch information
CJC-1295 No DAC 10mg Certificate of Analysis COA document

CJC-1295 No DAC (Mod GRF 1-29) 10mg – Lyophilized

$80.00

CJC-1295 No DAC, technically classified as Mod GRF 1-29 (Modified Growth Hormone Releasing Factor), is a tetrasubstituted, 29-amino acid peptide analogue of endogenous GHRH. This 10mg lyophilized vial represents the “short-acting” isoform of the CJC class, designed for researchers prioritizing pulsatile secretion modeling over continuous release.

Unlike the original GRF 1-29, which has a half-life of less than 10 minutes, Mod GRF 1-29 incorporates four specific amino acid substitutions. These structural modifications provide resistance to the DPP-IV enzyme, extending the half-life to approximately 30 minutes in animal models—sufficient to trigger a robust physiological signal without inducing pituitary desensitization.

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Description

What Is CJC-1295 (Mod GRF 1-29)?

CJC-1295 No DAC (Mod GRF 1-29) is a tetrasubstituted 29-amino-acid analog of growth hormone releasing hormone (GHRH). Four amino acid substitutions confer resistance to enzymatic degradation while maintaining GHRH receptor affinity. Research focuses on pulsatile GH release and somatotropic axis modulation. HPLC-verified at 99%+ purity with COA.

Why Researchers Choose CJC-1295 No DAC

  • Tetrasubstituted GHRH analog (Mod GRF 1-29) — specifically designed for pulsatile GH secretion research that mimics natural circadian patterns
  • DPP-IV enzyme resistance: four strategic amino acid substitutions extend half-life to approximately 30 minutes in preclinical models
  • Verified purity: ≥99% confirmed via third-party HPLC and mass spectrometry
  • Ideal for acute research protocols: pulsatile release profile enables precise GH pulse modeling without sustained receptor desensitization
  • Synergistic secretagogue research: published studies suggest enhanced GH output when combined with Ipamorelin in dual-pathway protocols

Frequently Asked Questions

What is CJC-1295 No DAC?

Also known as Mod GRF 1-29, CJC-1295 No DAC is a 29-amino acid growth hormone releasing hormone (GHRH) analog with four amino acid substitutions engineered for resistance to DPP-IV enzymatic degradation. Preclinical research indicates it produces pulsatile GH release in research models. This product is for laboratory research use only.

How do I reconstitute CJC-1295 No DAC?

Add 2 mL of bacteriostatic water to the 10 mg lyophilized vial for a concentration of 5 mg/mL. Follow standard reconstitution protocol — roll gently, do not shake. See our Reconstitution 101 guide for full instructions.

What purity verification is provided?

Every batch undergoes third-party HPLC analysis confirming ≥99% purity, along with mass spectrometry confirmation of molecular identity. A Certificate of Analysis (COA) is available for each lot.

How should I store CJC-1295 No DAC?

Lyophilized (powder): Store at -20°C for long-term storage or 2–8°C for short-term use. Reconstituted: Store at 2–8°C and use within 28 days. Protect from light and avoid repeated freeze-thaw cycles.

How does No DAC differ from With DAC?

CJC-1295 No DAC produces pulsatile (short burst) GH release with an approximately 30-minute half-life, making it ideal for research protocols that mimic natural GH secretion patterns. CJC-1295 With DAC produces sustained, continuous GH elevation with a multi-day half-life via albumin binding. The choice between them depends on whether the research design requires pulsatile or sustained GH modeling.

What published research exists on CJC-1295 No DAC?

CJC-1295 No DAC is indexed on PubMed under both “Mod GRF 1-29” and “CJC-1295.” Preclinical research covers GHRH analog mechanisms, pulsatile GH secretion modeling, and DPP-IV resistance pharmacokinetics. All available research is preclinical in nature.

Can CJC-1295 No DAC be combined with Ipamorelin in research?

Yes. This is one of the most studied GH secretagogue combinations in the literature. Published research suggests a synergistic “amplifier” effect on GH release when both the GHRH receptor (via CJC-1295) and the ghrelin receptor (via Ipamorelin) are activated simultaneously in preclinical models.

Further Reading

Technical Specifications

  • Synonyms: Mod GRF 1-29, Tetrasubstituted GRF 1-29

  • Sequence Length: 29 Amino Acids (Modified)

  • Purity: ≥99% (HPLC Verified)

  • Form: Lyophilized White Powder

  • Molar Mass: ~3367.9 g/mol

  • PubChem CID: 9924584

Mechanism: Natural Pulsatile Emulation

The primary research utility of CJC-1295 No DAC lies in its pharmacokinetic profile. Unlike the “DAC” (Drug Affinity Complex) variant, which binds to albumin for days creating a continuous “bleed” of growth hormone, Mod GRF 1-29 mimics the organism’s natural circadian rhythm.

  • Pulsatile Release: The approximate 30-minute half-life allows for distinct, high-amplitude spikes in Growth Hormone (GH) secretion followed by a return to baseline.

  • Pituitary Sensitivity: By avoiding the “GH bleed” associated with long-acting GHRH analogs, Mod GRF 1-29 minimizes the risk of downregulating GHRH receptors on the anterior pituitary. This makes it the preferred compound for studies attempting to emulate natural physiological signaling.

Research Synergy: The “GHRH + GHRP” Protocol

CJC-1295 No DAC is frequently utilized in conjunction with Ipamorelin or GHRP-6 to investigate neuroendocrine amplification. This pairing addresses the two rate-limiting factors of the somatotropic axis:

  1. The Accelerator (CJC-1295 No DAC): Acts as a Growth Hormone Releasing Hormone (GHRH) agonist, binding to pituitary receptors to stimulate GH production.

  2. The Brake Release (Ipamorelin): Acts as a Growth Hormone Releasing Peptide (GHRP), which mitigates the inhibitory effect of Somatostatin.

  3. The Outcome: Research suggests that co-administration creates a synergistic effect where the total GH release is significantly greater than the sum of the two peptides administered individually.

This research peptide undergoes rigorous quality control and stability testing to ensure maximum integrity for scientific applications. Each batch is manufactured under strict laboratory conditions and verified through independent laboratory analysis.⚠️ FOR RESEARCH PURPOSES ONLY

This product is strictly for in-vitro laboratory research, analysis, and development. It is not intended for human consumption, injection, or therapeutic use. CJC-1295 No DAC is not a drug, dietary supplement, or food. All statements regarding the physiological mechanisms are based on preclinical animal and cell-culture studies and are provided for educational and informational purposes only.

Storage & Handling

Peptides require careful storage to maintain their integrity and research effectiveness. Lyophilized peptides should be stored in a cold, dry, dark environment to prevent degradation. For short-term use within 4 weeks, storage at 4°C is sufficient, while long-term storage requires temperatures below -20°C or -80°C for extended periods up to 2 years. Always protect peptides from light exposure and avoid repeated freeze-thaw cycles, which can compromise structural integrity and research results.

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Legal Disclaimer & Safety Information

This product is sold as a pure research compound exclusively for laboratory research purposes and is not intended for use as a dietary supplement, medication, or for human/animal consumption. These research chemicals have not been evaluated by the U.S. Food and Drug Administration (FDA) and are not pharmaceuticals, medications, or dietary supplements. They have not received FDA approval for the treatment, prevention, diagnosis, mitigation, or cure of any disease, medical condition, or ailment. Keep this product out of the reach of children and unauthorized personnel, as this material may result in adverse effects if improperly handled or consumed. This product is for use and handling only by qualified professionals with the knowledge, training, and equipment to safely handle research chemicals. Under no circumstances should these products be utilized as drugs, agricultural or pesticide products, food additives, or household chemicals, and any form of introduction into the human or animal body is prohibited by law. By making a purchase from Peptideware, you acknowledge that you are acquiring research chemicals exclusively intended for in-vitro laboratory research use by qualified and licensed professionals only. All articles, information, and product descriptions provided on this website are strictly for educational and informational purposes. We attest exclusively to the quality, purity, and description of the materials we provide. Misrepresentation of these products for unauthorized purposes is strictly prohibited by law. You agree to indemnify and hold us harmless for any adverse effects, claims, expenses, losses, and liabilities that may arise from improper handling, misuse, or consumption of this product. Please refer to our terms and conditions prior to purchase.