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CJC-1295 with DAC 5mg long-acting albumin-bound growth hormone peptide
CJC-1295 with DAC 5mg research vial label with batch information
CJC-1295 with DAC 5mg Certificate of Analysis COA document
CJC-1295 with DAC 5mg long-acting albumin-bound growth hormone peptide
CJC-1295 with DAC 5mg research vial label with batch information
CJC-1295 with DAC 5mg Certificate of Analysis COA document

CJC-1295 With DAC (Long-Acting) 5mg – Albumin Bound Complex

Original price was: $80.00.Current price is: $65.00.

CJC-1295 With DAC is a synthetic modification of Growth Hormone Releasing Factor (GRF 1-29) engineered for exceptional biostability. This 5mg lyophilized vial features a specific chemical conjugation known as the Drug Affinity Complex (DAC), which fundamentally alters the pharmacokinetic profile of the peptide.

Unlike standard GHRH analogs that degrade rapidly, this “With DAC” variant is the primary compound of choice for research protocols requiring sustained, non-pulsatile stimulation of the pituitary gland over extended durations.

PeptideHub Research Usage∗

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SKU: pw-cjd-05 Categories: , ,

Description

What Is CJC-1295 With DAC?

CJC-1295 With DAC is a modified GRF 1-29 analog conjugated with a Drug Affinity Complex (DAC) that enables albumin binding, extending the half-life to approximately 8 days. This enables sustained, non-pulsatile growth hormone elevation for extended pharmacokinetic research models. HPLC-verified at 99%+ purity with publicly available COA.

Why Researchers Choose CJC-1295 With DAC

  • Drug Affinity Complex (DAC) modification — enables sustained, non-pulsatile GH elevation research not achievable with standard GHRH analogs
  • Extended pharmacokinetics: albumin-bound complex extends half-life to multiple days in preclinical pharmacokinetic models
  • Verified purity: ≥99% confirmed via third-party HPLC and mass spectrometry
  • 5 mg lyophilized format: specifically designed for longitudinal metabolic research protocols requiring infrequent administration
  • Unique sustained GH release profile: continuous, steady-state elevation provides a research model distinct from pulsatile secretagogues

Frequently Asked Questions

What is CJC-1295 With DAC?

CJC-1295 With DAC is a modified growth hormone releasing hormone (GHRH) analog featuring a Drug Affinity Complex that enables sustained GH elevation via covalent albumin binding. It is investigated in preclinical research for longitudinal metabolic and body composition modeling. This product is for laboratory research use only.

How do I reconstitute CJC-1295 With DAC?

Add 2 mL of bacteriostatic water to the 5 mg lyophilized vial for a concentration of 2.5 mg/mL. Follow standard reconstitution protocol — roll gently, do not shake. See our Reconstitution 101 guide for full instructions.

What purity verification is provided?

Every batch undergoes third-party HPLC analysis confirming ≥99% purity, along with mass spectrometry confirmation of molecular identity. A Certificate of Analysis (COA) is available for each lot.

How should I store CJC-1295 With DAC?

Lyophilized (powder): Store at -20°C for long-term storage or 2–8°C for short-term use. Reconstituted: Store at 2–8°C and use within 28 days. Protect from light and avoid repeated freeze-thaw cycles.

How does With DAC differ from No DAC?

CJC-1295 With DAC produces sustained, multi-day non-pulsatile GH elevation via covalent albumin binding. CJC-1295 No DAC (Mod GRF 1-29) produces acute pulsatile GH release with an approximately 30-minute half-life. The choice between them depends on the research design: sustained elevation models versus pulsatile secretion models.

What published research exists on CJC-1295 With DAC?

CJC-1295 With DAC is indexed on PubMed with preclinical research covering sustained GH elevation, albumin-binding pharmacokinetics, and body composition modeling in animal studies. All available research is preclinical in nature.

Can CJC-1295 With DAC be combined with other peptides in research?

Yes. CJC-1295 With DAC is investigated alongside Ipamorelin and other GH secretagogues in published research models. The sustained release profile of the DAC variant complements the acute selectivity of Ipamorelin, targeting both the GHRH and ghrelin receptor pathways simultaneously.

Further Reading

Mechanism: Drug Affinity Complex (DAC)

The defining characteristic of this peptide is the addition of a reactive lysine linker at the C-terminus.

  • Albumin Binding: Upon introduction to the research subject, this reactive linker forms a covalent bond with endogenous serum albumin.

  • Enzymatic Shielding: This albumin conjugation acts as a protective shield, preventing degradation by the enzyme DPP-IV.

  • Extended Half-Life: While standard Mod GRF 1-29 has a half-life of roughly 30 minutes, the DAC complex extends the half-life to approximately 6–8 days in animal models.

  • Continuous Elevation: The result is a physiological “GH Bleed”—a continuous, steady-state elevation of Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF-1) levels, rather than the natural pulsatile release seen with unmodified secretagogues.

⚠️ Critical Research Distinction

Please verify your research protocol before purchase.

  • THIS PRODUCT (CJC-1295 With DAC): Provides continuous, long-acting GH elevation for days.

  • CJC-1295 No DAC (Mod GRF): Provides short-acting, pulsatile spikes aimed at mimicking natural circadian rhythms.

This research peptide undergoes rigorous quality control and stability testing to ensure maximum integrity for scientific applications. Each batch is manufactured under strict laboratory conditions and verified through independent laboratory analysis.⚠️ FOR RESEARCH PURPOSES ONLY

This product is strictly for in-vitro laboratory research, analysis, and development. It is not intended for human consumption, injection, or therapeutic use. CJC-1295 With DAC is not a drug, dietary supplement, or food. All statements regarding the physiological mechanisms of this peptide are based on preclinical animal and cell-culture studies and are provided for educational and informational purposes only.

Usage Context: Longitudinal Studies

The 5mg concentration is specifically optimized for longitudinal research studies where minimizing subject stress is a priority.

  • Infrequent Administration: Due to the multi-day half-life, this compound allows for once-weekly administration protocols.

  • Reduced Handling: This reduction in injection frequency is advantageous for reducing physiological stress markers in laboratory animals, potentially yielding cleaner data regarding long-term IGF-1 elevation.

Technical Specifications

  • Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Maleimidopropionic acid)-NH2

  • Conjugation: Drug Affinity Complex (Maleimidopropionic acid)

  • Purity: ≥99% (HPLC Verified)

  • Form: Lyophilized White Powder

  • Solubility: Water Soluble (Reconstitute with Bacteriostatic Water)

  • Peptideware Cjc1295dac Ms
  • Peptideware Cjc1295dac Lc
  • CJC-1295 DAC Certificate of Analysis from independent third-party laboratory

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Legal Disclaimer & Safety Information

This product is sold as a pure research compound exclusively for laboratory research purposes and is not intended for use as a dietary supplement, medication, or for human/animal consumption. These research chemicals have not been evaluated by the U.S. Food and Drug Administration (FDA) and are not pharmaceuticals, medications, or dietary supplements. They have not received FDA approval for the treatment, prevention, diagnosis, mitigation, or cure of any disease, medical condition, or ailment. Keep this product out of the reach of children and unauthorized personnel, as this material may result in adverse effects if improperly handled or consumed. This product is for use and handling only by qualified professionals with the knowledge, training, and equipment to safely handle research chemicals. Under no circumstances should these products be utilized as drugs, agricultural or pesticide products, food additives, or household chemicals, and any form of introduction into the human or animal body is prohibited by law. By making a purchase from Peptideware, you acknowledge that you are acquiring research chemicals exclusively intended for in-vitro laboratory research use by qualified and licensed professionals only. All articles, information, and product descriptions provided on this website are strictly for educational and informational purposes. We attest exclusively to the quality, purity, and description of the materials we provide. Misrepresentation of these products for unauthorized purposes is strictly prohibited by law. You agree to indemnify and hold us harmless for any adverse effects, claims, expenses, losses, and liabilities that may arise from improper handling, misuse, or consumption of this product. Please refer to our terms and conditions prior to purchase.