Melanotan II MT-2 10mg cyclic lactam melanocortin peptide for research
Melanotan II MT-2 10mg research vial label with batch information
Melanotan II MT-2 10mg Certificate of Analysis COA document
Melanotan II MT-2 10mg cyclic lactam melanocortin peptide for research
Melanotan II MT-2 10mg research vial label with batch information
Melanotan II MT-2 10mg Certificate of Analysis COA document

Melanotan II (MT-2) 10mg – Alpha-MSH Analog

$35.00

Melanotan II (MT-2) is a synthetic, cyclic lactam analog of the naturally occurring peptide hormone Alpha-Melanocyte Stimulating Hormone (α-MSH). This 10mg lyophilized peptide is a critical tool for investigating the physiology of the melanocortin system.

Unlike linear peptides, MT-2 features a specific lactam bridge structure that significantly increases its half-life and binding affinity. It is widely utilized in research protocols aimed at understanding neuroendocrine signaling, pigmentation pathways, and metabolic homeostasis.

PeptideHub Research Usage∗

Available on backorder

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Description

What Is Melanotan II?

Melanotan II (MT-2) is a synthetic cyclic lactam analog of alpha-MSH (MW: 1,024.2 Da, CAS: 121062-08-6). It is a non-selective melanocortin receptor agonist (MC1R-MC5R) developed at the University of Arizona. Research covers melanogenesis, metabolic homeostasis, appetite regulation, and CNS signaling pathways. HPLC-verified at 99%+ purity.

Why Researchers Choose Melanotan II

  • Cyclic Lactam Structure: The lactam bridge between Asp and Lys residues extends half-life and enhances receptor binding affinity compared to linear analogs.
  • Broad Melanocortin Receptor Affinity: Non-selective agonist spanning MC1R through MC5R, enabling multi-pathway neuroendocrine signaling research.
  • Verified Purity: Every batch is HPLC-verified at ≥99% purity with full Certificate of Analysis provided.
  • Established Research Compound: Published studies investigate pigmentation pathways, metabolic homeostasis, and central nervous system signaling via melanocortin receptors.
  • Neuroendocrine Signaling Tool: Preclinical research indicates MT-2 crosses the blood-brain barrier in animal models, making it valuable for hypothalamic receptor studies.
  • Currently on Backorder: High demand — join the waitlist to be notified when stock is replenished.

Frequently Asked Questions

What is Melanotan II (MT-2)?Melanotan II is a synthetic cyclic lactam analog of alpha-melanocyte-stimulating hormone (α-MSH). It was originally developed at the University of Arizona and is widely used in research protocols investigating the melanocortin receptor system, including pigmentation pathways, energy homeostasis, and neuroendocrine signaling.

How do I reconstitute Melanotan II?For a 10mg vial, add 2mL of bacteriostatic water to achieve a concentration of 5mg/mL. Direct the stream of solvent down the inside wall of the vial — never spray directly onto the lyophilized powder. Allow the powder to dissolve through gentle swirling; do not shake or vortex.

What purity standard does Peptideware MT-2 meet?Each batch undergoes HPLC analysis and is verified at ≥99% purity. A Certificate of Analysis accompanies every order, documenting purity, molecular weight confirmation, and peptide content.

How should Melanotan II be stored?Store lyophilized (unreconstituted) MT-2 at -20°C for long-term storage or 2–8°C for short-term use within 4 weeks. After reconstitution, store at 2–8°C in an amber vial or light-proof container and use within 28 days. MT-2 is UV-sensitive — avoid direct sunlight exposure.

How does MT-2 differ from KPV?Melanotan II is a full melanocortin receptor agonist with affinity for MC1R–MC5R, making it relevant to pigmentation, metabolic, and CNS research. KPV is a tripeptide fragment of α-MSH (Lys-Pro-Val) studied primarily for its anti-inflammatory properties via NF-κB inhibition — it does not activate pigmentation pathways. They serve fundamentally different research applications.

What areas of research use Melanotan II?Published studies investigate MT-2 across multiple domains: melanocortin-mediated pigmentation (MC1R), appetite and metabolic regulation (MC3R/MC4R), central nervous system signaling, and sexual function pathways. Preclinical research indicates broad utility as a tool compound for understanding the melanocortin receptor family.

Related Research

Further Reading

Multifaceted Receptor Agonism

The primary research value of Melanotan II lies in its non-selective agonist activity. It exhibits high affinity for multiple subtypes of the melanocortin receptor family, allowing for a diverse range of physiological investigations:

  • MC1R (Melanogenesis): MT-2 is chemically designed to bind to the Melanocortin-1 Receptor (MC1R). Research studies focus on its ability to upregulate the synthesis of eumelanin (photoprotective pigment) within melanocytes, independent of UV radiation exposure.

  • MC3R & MC4R (Metabolic & CNS Signaling): By crossing the blood-brain barrier in animal models, MT-2 interacts with MC3 and MC4 receptors in the hypothalamus.

    • Energy Balance: These receptors are key regulators of energy homeostasis. Studies investigate how MC4R activation influences appetite suppression and metabolic rate.

    • Sexual Function: Activation of central MC3/MC4 receptors is studied for its role in the neurogenic pathways of sexual arousal and erectile function, mediating signals through the central nervous system rather than vascular mechanisms alone.

This research peptide undergoes rigorous quality control and stability testing to ensure maximum integrity for scientific applications. Each batch is manufactured under strict laboratory conditions and verified through independent laboratory analysis.⚠️ FOR RESEARCH PURPOSES ONLY

Technical Specifications

  • Chemical Name: Melanotan II (MT-II)

  • Sequence: Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2 (Cyclic)

  • CAS Number: 121062-08-6

  • Formula: C₅₀H₆₉N₁₅O₉

  • Molar Mass: 1024.2 g/mol

  • Purity: ≥99% (HPLC Verified)

  • Form: Lyophilized White Powder

⚠️ Research Note: Photostability & Handling

UV Sensitivity Warning: Melanotan II is sensitive to ultraviolet (UV) light degradation, particularly after reconstitution in solution.

  • Storage: Reconstituted vials should be stored in amber glass containers or kept in a light-proof box within the refrigerator.

  • Handling: Avoid leaving the vial exposed to direct sunlight or intense laboratory lighting for extended periods, as this may compromise the peptide’s structural integrity and binding affinity.

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Legal Disclaimer & Safety Information

This product is sold as a pure research compound exclusively for laboratory research purposes and is not intended for use as a dietary supplement, medication, or for human/animal consumption. These research chemicals have not been evaluated by the U.S. Food and Drug Administration (FDA) and are not pharmaceuticals, medications, or dietary supplements. They have not received FDA approval for the treatment, prevention, diagnosis, mitigation, or cure of any disease, medical condition, or ailment. Keep this product out of the reach of children and unauthorized personnel, as this material may result in adverse effects if improperly handled or consumed. This product is for use and handling only by qualified professionals with the knowledge, training, and equipment to safely handle research chemicals. Under no circumstances should these products be utilized as drugs, agricultural or pesticide products, food additives, or household chemicals, and any form of introduction into the human or animal body is prohibited by law. By making a purchase from Peptideware, you acknowledge that you are acquiring research chemicals exclusively intended for in-vitro laboratory research use by qualified and licensed professionals only. All articles, information, and product descriptions provided on this website are strictly for educational and informational purposes. We attest exclusively to the quality, purity, and description of the materials we provide. Misrepresentation of these products for unauthorized purposes is strictly prohibited by law. You agree to indemnify and hold us harmless for any adverse effects, claims, expenses, losses, and liabilities that may arise from improper handling, misuse, or consumption of this product. Please refer to our terms and conditions prior to purchase.