Description
The DAC Advantage: Extending Stability
Native MOTS-c exhibits a notoriously short plasma half-life (often <30 minutes) due to rapid enzymatic degradation, which limits its utility in extended time-course studies.
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Enhanced Half-Life: The addition of the Drug Affinity Complex (DAC) creates a protective conjugation that allows the peptide to bind non-covalently to plasma albumin. This shielding effect significantly protects the peptide from peptidase cleavage.
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Longitudinal Research: This modification extends the window of bioactivity, allowing researchers to investigate metabolic effects over hours or days rather than minutes, providing a more robust model for systemic metabolic regulation.
Mechanism: Metabolic Regulation & Exercise Mimicry
MOTS-c is frequently categorized in research literature as an “exercise mimetic” due to its downstream effects on cellular energy handling.
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AMPK Activation: Upon administration, MOTS-c is observed to target the Folate-Methionine Cycle, leading to an increase in AICAR levels. This accumulation triggers the phosphorylation of AMPK (AMP-activated protein kinase), the cellular “master switch” for energy metabolism.
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Glucose & Fatty Acid Oxidation: Through AMPK activation, MOTS-c is studied for its ability to promote glucose uptake in skeletal muscle and enhance fatty acid oxidation, mimicking the physiological response to endurance exercise without mechanical stress.
Technical Specifications
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Sequence (Native): Met-Arg-Trp-Qln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
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Modification: Drug Affinity Complex (DAC) Conjugation
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Concentration: 10mg Lyophilized Powder
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Purity: ≥99% (HPLC Verified)
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Research Target: Metabolic Homeostasis, Insulin Sensitivity, Mitochondrial Biogenesis
This research peptide undergoes rigorous quality control and stability testing to ensure maximum integrity for scientific applications. Each batch is manufactured under strict laboratory conditions and verified through independent laboratory analysis.
⚠️ FOR RESEARCH PURPOSES ONLY
This product is strictly for in-vitro laboratory research, analysis, and development. It is not intended for human consumption, weight loss, performance enhancement, or therapeutic use. All statements regarding the physiological mechanisms of MOTS-c are based on preclinical animal and cell-culture studies and are provided for educational and informational purposes only.
⚠️ Technical Handling: Solubility & Reconstitution
CRITICAL RESEARCH NOTE: MOTS-c peptides possess hydrophobic properties that can make reconstitution challenging compared to standard peptides.
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Visual Clarity: Upon adding bacteriostatic water, the solution may appear cloudy or contain precipitate.
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Titration Protocol: If the peptide does not fully dissolve, research protocols often suggest titrating with a small amount (0.1mL – 0.5mL) of dilute acetic acid or a specific pH buffer to aid solubilization before diluting to volume.
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Gentle Handling: Do not shake vigorously. High-velocity agitation can damage the peptide structure (fibrillation). Use gentle swirling or a slow roller mixer.
Storage & Handling
Peptides require careful storage to maintain their integrity and research effectiveness. Lyophilized peptides should be stored in a cold, dry, dark environment to prevent degradation. For short-term use within 4 weeks, storage at 4°C is sufficient, while long-term storage requires temperatures below -20°C or -80°C for extended periods up to 2 years. Always protect peptides from light exposure and avoid repeated freeze-thaw cycles, which can compromise structural integrity and research results.
