TB-500 Thymosin Beta-4 10mg lyophilized peptide for cell migration research
TB-500 Thymosin Beta-4 10mg lyophilized powder detail view in research vial
TB-500 Thymosin Beta-4 10mg Certificate of Analysis COA document
TB-500 Thymosin Beta-4 10mg lyophilized peptide for cell migration research
TB-500 Thymosin Beta-4 10mg lyophilized powder detail view in research vial
TB-500 Thymosin Beta-4 10mg Certificate of Analysis COA document

TB-500 (Thymosin Beta-4) 10mg – Lyophilized Research Peptide

$60.00

TB-500 is a premium, synthetic version of the naturally occurring peptide Thymosin Beta-4 (Tβ4). This 10mg lyophilized vial contains the full 43 amino acid sequence responsible for regulating actin polymerization and cytoskeletal organization. It is a fundamental compound in regenerative biology research, specifically regarding cell migration, inflammation modulation, and soft tissue remodeling.

Our TB-500 is manufactured for high-intent research applications, ensuring ≥99% purity via HPLC analysis to eliminate contamination and ensure reproducible experimental data.

PeptideHub Research Usage∗

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SKU: pw-tb500-10 Categories: , ,

Description

What Is TB-500?

TB-500 is a synthetic 43-amino-acid peptide (MW: 4,963 Da, CAS: 77591-33-4) corresponding to the active region of thymosin beta-4, a naturally occurring protein regulating actin polymerization and cell migration. Published in Nature, TB-500 promoted cardiomyocyte survival after myocardial infarction. Studied for wound healing, cardiac repair, and anti-inflammatory effects. HPLC-verified at 99%+ purity with publicly available COA.

Why Researchers Choose TB-500

  • Full 43-amino acid synthetic Thymosin Beta-4 sequence for comprehensive cell migration research
  • Extensively studied for actin polymerization regulation and cytoskeletal organization pathways
  • ≥99% purity verified via independent third-party HPLC and mass spectrometry analysis
  • Well-documented synergy potential with BPC-157 in published preclinical literature
  • Versatile reconstitution compatibility with standard bacteriostatic water protocols

Frequently Asked Questions

What is TB-500 and what research applications does it support?

TB-500 is a synthetic version of naturally occurring Thymosin Beta-4 (Tβ4), a 43-amino acid peptide that regulates actin polymerization and cytoskeletal organization. In preclinical research, it has been investigated for cell migration, inflammation modulation, and soft tissue remodeling. All Peptideware TB-500 is provided for laboratory research purposes only.

How do I reconstitute TB-500 for laboratory use?

To reconstitute TB-500 10mg, add 2mL of bacteriostatic water to the vial using a sterile syringe, directing the stream against the glass wall. This produces a concentration of 5mg/mL. Gently roll the vial to dissolve — never shake. Refer to our Reconstitution 101 guide for complete step-by-step protocols.

What purity verification does Peptideware provide for TB-500?

Every batch of Peptideware TB-500 is independently tested by third-party laboratories. HPLC analysis confirms ≥99% purity, and mass spectrometry verifies molecular weight and full 43-amino acid sequence integrity. Certificates of Analysis are available for every batch.

How should I store TB-500 before and after reconstitution?

Store lyophilized TB-500 at -20°C for long-term stability or at 2-8°C for short-term use. After reconstitution with bacteriostatic water, refrigerate at 2-8°C and use within 28 days to maintain research-grade consistency.

How does TB-500 differ from BPC-157 in research applications?

TB-500 is primarily investigated for cell migration through actin sequestration mechanisms, while BPC-157 focuses on cytoprotective and angiogenic pathways. TB-500 works through the central actin-binding domain (amino acids 17-23), whereas BPC-157 operates through VEGF and nitric oxide signaling. Preclinical research indicates they engage complementary pathways.

What published research exists on TB-500?

Thymosin Beta-4, the parent molecule of TB-500, has been studied since its identification in 1981. Research spans cell migration, wound modeling, inflammation, and actin biology. Published studies are available on PubMed under ‘Thymosin Beta-4.’ All referenced findings are from preclinical research models.

Can TB-500 be used in combination research protocols?

Yes. TB-500 is commonly investigated alongside BPC-157 in synergy research. Peptideware offers the GLOW Blend (BPC-157 + TB-500 + GHK-Cu) and KLOW Blend (adding KPV) for researchers studying multi-peptide regenerative protocols.

Further Reading

Mechanism of Action: Actin Sequestration

The primary research interest in TB-500 lies in its ability to interact with G-actin (globular actin).

  • Actin Buffering: In laboratory models, TB-500 acts as a major actin-sequestering molecule. By binding to monomeric G-actin, it maintains a reservoir of actin monomers preventing premature polymerization.

  • Cell Migration: When a cell receives a signal to migrate (chemotaxis), TB-500 releases the sequestered actin. This rapid availability allows for the immediate polymerization of actin filaments (F-actin) at the leading edge of the cell, facilitating the formation of lamellipodia and filopodia. This process is critical for researching accelerated cell motility toward sites of tissue damage.

Synergistic Research: The BPC-157 Pairing

TB-500 is frequently co-administered with BPC-157 in tissue repair studies. The theoretical synergy is often described in research literature through a functional division of labor:

  • Vascular Infrastructure (BPC-157): Research suggests BPC-157 promotes angiogenesis (the formation of new blood vessels) via the VEGF pathway, effectively “building the road” to the injury site.

  • Cellular Mobilization (TB-500): TB-500 is observed to drive the migration of endothelial and keratinocyte cells, effectively “mobilizing the workforce” to travel down that road.

  • Conclusion: The combined administration is investigated for its potential to simultaneously support blood flow and cellular recruitment, offering a comprehensive model for soft tissue analysis.

  • GLOW: This is apart of the GLOW Peptide Stack (BPC-157 + TB-500 + GHK-Cu) – 70mg Blend

TB-500 is often combined with BPC-157 and GHK-Cu, which is also known as “GLOW”

This research peptide undergoes rigorous quality control and stability testing to ensure maximum integrity for scientific applications. Each batch is manufactured under strict laboratory conditions and verified through independent laboratory analysis.⚠️ FOR RESEARCH PURPOSES ONLY

This product is strictly for in-vitro laboratory research, analysis, and development. It is not intended for human consumption, injection, or therapeutic use. TB-500 is not a drug, dietary supplement, or food. All statements regarding the physiological mechanisms of Thymosin Beta-4 are based on preclinical animal and cell-culture studies and are provided for educational and informational purposes only.

Storage and Handling:

Peptides require careful storage to maintain their integrity and research effectiveness. Lyophilized peptides should be stored in a cold, dry, dark environment to prevent degradation. For short-term use within 4 weeks, storage at 4°C is sufficient, while long-term storage requires temperatures below -20°C or -80°C for extended periods up to 2 years. Always protect peptides from light exposure and avoid repeated freeze-thaw cycles, which can compromise structural integrity and research results.

Technical Specifications: Thymosin Beta-4

This product contains the correct full-sequence Thymosin Beta-4 data.

Specification Detail
Peptide Sequence Ac-Ser-Asp-Lys-Pro-Asp-Moe-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Klys-Leu-Lys-Lys-Thr-Ete-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Eshe-Ser (43 Amino Acids)
CAS Number 77591-33-4
Molecular Formula C₂₁₂H₃₅₀N₅₆O₇₈S
Molar Mass 4963.5 g/mol
Purity ≥99% (HPLC Verified)
Form Lyophilized White Powder
  • TB-500 Certificate of Analysis showing third-party purity verification
  • Peptideware Lc Tb500 5mg 10mg Optimized
  • TB-500 mass spectrometry analysis confirming molecular weight and identity

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Legal Disclaimer & Safety Information

This product is sold as a pure research compound exclusively for laboratory research purposes and is not intended for use as a dietary supplement, medication, or for human/animal consumption. These research chemicals have not been evaluated by the U.S. Food and Drug Administration (FDA) and are not pharmaceuticals, medications, or dietary supplements. They have not received FDA approval for the treatment, prevention, diagnosis, mitigation, or cure of any disease, medical condition, or ailment. Keep this product out of the reach of children and unauthorized personnel, as this material may result in adverse effects if improperly handled or consumed. This product is for use and handling only by qualified professionals with the knowledge, training, and equipment to safely handle research chemicals. Under no circumstances should these products be utilized as drugs, agricultural or pesticide products, food additives, or household chemicals, and any form of introduction into the human or animal body is prohibited by law. By making a purchase from Peptideware, you acknowledge that you are acquiring research chemicals exclusively intended for in-vitro laboratory research use by qualified and licensed professionals only. All articles, information, and product descriptions provided on this website are strictly for educational and informational purposes. We attest exclusively to the quality, purity, and description of the materials we provide. Misrepresentation of these products for unauthorized purposes is strictly prohibited by law. You agree to indemnify and hold us harmless for any adverse effects, claims, expenses, losses, and liabilities that may arise from improper handling, misuse, or consumption of this product. Please refer to our terms and conditions prior to purchase.